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纳米抗体文库构建

As the understanding of the antibody repertoire accumulation,the naive library and synthetic library

which is devoid of animals, has attracted attention widely in recent years.

纳米抗体文库构建

纳米抗体天然库

前言纳米抗体(VHH)因其独特的理化性质可以作为治疗分子和临床诊断工具，而纳米抗体需要对纳米抗体文库进行淘筛来获取。目前纳米抗体文库可以分为三类，包括天然库，免疫库和合成库。天然库的VHH基因来源于未经免疫的羊驼B淋巴细胞，免疫库的VHH基因来源于经某种特定抗原免…
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Immune sdAb Libraries

The nave sdAb library is unique in which the sdAbs gene repertoire used is generally from non-immune animals, unspecific randomaly, and no preferred antigen for any antibody subpopulations.
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Humanized Synthetic sdAb Library

The design and generation of a humanized artificial synthetic VHH library involve several steps. First, the sequences of the VHHs derived from camelids are analyzed, and the CDRs (Complementarity Determining Regions) are identified. Then, the CDRs are…
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